 Shaffar's Wrappings#28490 · Quest items | 1 | — | No equipment slot | Common |
 Shaffar's Stasis Chamber Key#32079 · Keys | 1 | — | No equipment slot | Uncommon |
 Shaffar's Wondrous Amulet#33835 · Quest items | 1 | — | No equipment slot | Common |
 Shango's Pelt#38523 · Quest items | 1 | — | No equipment slot | Common |
 Shani's Crysknife#31759 · Weapons | 94 | — | One-hand | Rare |
 Shawn's Super Special Swami Hat#12904 · Armor | 61 | 61 | Head | Uncommon |
 Shaw's Report#1353 · Quest items | 1 | — | No equipment slot | Common |
 Shay's Bell#9189 · Quest items | 1 | — | No equipment slot | Common |
 Shekketh Talons#25187 · Weapons | 90 | 60 | Off hand | Uncommon |
 Shiffar's Nexus-Horn#28418 · Armor | 115 | 70 | Trinket | Rare |
 Shindrell's Note#12060 · Quest items | 1 | — | No equipment slot | Common |
 Shinsollo#16171 · Consumables | 55 | 45 | No equipment slot | Common |
 Shoni's Disarming Tool#9608 · Weapons | 31 | — | Off hand | Uncommon |
 Shuriken of Negation#28826 · Weapons | 125 | 70 | Thrown | Epic |
 Serpentshrine Shuriken#30025 · Weapons | 134 | 70 | Thrown | Epic |
 SI:7 Insignia (Fredo)#16001 · Quest items | 1 | — | No equipment slot | Common |
| SI:7 Insignia (Rutger)#16003 · Quest items | 1 | — | No equipment slot | Common |
| SI:7 Insignia (Turyen)#16002 · Quest items | 1 | — | No equipment slot | Common |
 Crescent of Forlorn Spirits#2044 · Weapons | 35 | — | One-hand | Rare |
 Sickle of Unyielding Strength#21392 · Weapons | 70 | 60 | One-hand | Epic |
 Crescent of Brooding Fury#44735 · Weapons | 175 | — | One-hand | Rare |
| Sickle Axe#1602 · Weapons | 39 | 34 | One-hand | Rare |
 Crescent Axe#2522 · Weapons | 35 | 30 | Main hand | Common |
 Crescent Edge#15235 · Weapons | 48 | 43 | One-hand | Uncommon |
 Salvaged Ethereum Prison Key#31956 · Keys | 1 | — | No equipment slot | Common |
 Finding Security and Comfort in a Doomed World#52565 · Quest items | 1 | 1 | No equipment slot | Common |
 Welldrip Gloves#15401 · Armor | 14 | — | Hands | Common |
 Seeping Willow#12969 · Weapons | 63 | 58 | Two-hand | Rare |
 Sida's Bag#3349 · Quest items | 1 | — | No equipment slot | Common |
 Seven of Nobles#44274 · Quest items | 1 | — | No equipment slot | Rare |