 Singing Dagger#36679 · Weapons | 170 | 77 | Main hand | Uncommon |
 Singing Crystal Shard#3918 · Quest items | 1 | — | No equipment slot | Common |
 Songbird Blouse#13378 · Armor | 58 | 53 | Chest | Rare |
 Sinister Revenge#40386 · Weapons | 226 | 80 | One-hand | Epic |
 Sinok's Key Fragment#36754 · Quest items | 1 | — | No equipment slot | Common |
 Sintar's Vaccine#36807 · Quest items | 1 | — | No equipment slot | Common |
 Siren's Tear#36784 · Gems | 75 | — | No equipment slot | Rare |
 Whistling Sword#31541 · Weapons | 108 | — | One-hand | Uncommon |
 Sixen's Skullcap#43840 · Armor | 174 | — | Head | Uncommon |
 Sjonnir's Girdle#37670 · Armor | 200 | 80 | Waist | Epic |
 Skadi's Iron Belt#37379 · Armor | 200 | 80 | Waist | Rare |
 Bloodscalp Scalp#6850 · Quest items | 1 | — | No equipment slot | Common |
 Thunderlord Scalpel#31475 · Weapons | 105 | — | Main hand | Uncommon |
 Scalpel of the Royal Apothecary#45214 · Weapons | 200 | 80 | Main hand | Epic |
 Scalpel-Sharpening Shoulderguards#51014 · Armor | 251 | 80 | Shoulder | Epic |
 Scalpel-Sharpening Shoulderguards#51865 · Armor | 264 | 80 | Shoulder | Epic |
 Scalping Tomahawk#4561 · Weapons | 11 | 6 | Main hand | Uncommon |
 Scarab of Displacement#30629 · Armor | 128 | 70 | Trinket | Epic |
 Scarab of the Infinite Cycle#28190 · Armor | 115 | 70 | Trinket | Rare |
 Scarab of Isanoth#38081 · Armor | 146 | — | Trinket | Uncommon |
 Scarab Trousers#6659 · Armor | 20 | — | Legs | Uncommon |
| Scarab Brooch#21625 · Armor | 78 | 60 | Trinket | Epic |
 Scarab Plate Helm#18480 · Armor | 60 | 55 | Head | Uncommon |
 Scarab Bag#21156 · Miscellaneous | 1 | — | No equipment slot | Common |
 Skarvald's Dragonskin Habergeon#35575 · Armor | 155 | 70 | Chest | Rare |
 Skeletal Broadsword#25158 · Weapons | 87 | 59 | Two-hand | Uncommon |
 Skeleton Finger#2378 · Quest items | 1 | — | No equipment slot | Common |
 Skeletal Fragments#14619 · Quest items | 1 | — | No equipment slot | Common |
 Skeletal Hacker#36583 · Weapons | 178 | 79 | One-hand | Uncommon |
 Skeletal Necklace of Battlerage#27551 · Armor | 115 | 70 | Neck | Rare |