 Senir's Report#2628 · Quest items | 1 | — | No equipment slot | Common |
 Scythe of the Unseen Path#21401 · Weapons | 70 | 60 | One-hand | Epic |
 Scythe Axe#5749 · Weapons | 23 | 18 | Two-hand | Uncommon |
 Scytheclaw Boots#35641 · Armor | 171 | 74 | Feet | Rare |
 Scything Talon#36802 · Miscellaneous | 1 | — | No equipment slot | Poor |
 Cuttlesteak#42998 · Consumables | 80 | 70 | No equipment slot | Common |
 Cuttlefish Scale Breastplate#44059 · Armor | 166 | 76 | Chest | Rare |
 Cuttlefish Tooth Ringmail#44060 · Armor | 166 | 76 | Chest | Rare |
 Seraph's Strike#5614 · Weapons | 31 | — | Two-hand | Uncommon |
 Serathil#13015 · Weapons | 61 | 56 | One-hand | Rare |
 Serena's Head#5067 · Quest items | 1 | — | No equipment slot | Common |
 Serilas, Blood Blade of Invar One-Arm#45947 · Weapons | 232 | 80 | One-hand | Epic |
 Serpentine Chain#36439 · Armor | 162 | 75 | Neck | Uncommon |
 Serpentine Skuller#12605 · Weapons | 56 | 51 | Ranged | Rare |
 Serpentine Sash#13118 · Armor | 57 | 52 | Waist | Rare |
 Serpentine Loop#11977 · Armor | 55 | 50 | Finger | Uncommon |
 Serrah's Star#37559 · Armor | 138 | — | Trinket | Uncommon |
 NPC Equip 47842#47842 · Trade goods | 0 | — | No equipment slot | Poor |
 Servomechanic Sledgehammer#4548 · Weapons | 41 | — | Two-hand | Uncommon |
 Sethir's Journal#7737 · Quest items | 1 | 1 | No equipment slot | Common |
 Seth's Graphite Fishing Pole#25978 · Weapons | 60 | — | Two-hand | Uncommon |
 Plague Band#34658 · Armor | 60 | 55 | Finger | Uncommon |
 Plague-Infested Quilboar Mane#10650 · Quest items | 0 | — | No equipment slot | Common |
 Plague-Soaked Leather Leggings#50858 · Armor | 251 | 80 | Legs | Epic |
| Plague-Soaked Leather Leggings#51889 · Armor | 264 | 80 | Legs | Epic |
 Plaguerot Sprig#10766 · Weapons | 40 | 35 | Ranged | Rare |
 Plague-Impervious Boots#39234 · Armor | 200 | 80 | Feet | Epic |
 Flask of Blight#37129 · Quest items | 1 | — | No equipment slot | Common |
 Plague Shooter#33604 · Quest items | 1 | — | Ranged | Common |
 Plaguehound Leggings#18736 · Armor | 62 | 57 | Legs | Rare |