 SI:7 Insignia (Fredo)#16001 · Quest items | 1 | — | No equipment slot | Common |
 Serpentshrine Shuriken#30025 · Weapons | 134 | 70 | Thrown | Epic |
 Shuriken of Negation#28826 · Weapons | 125 | 70 | Thrown | Epic |
 Shoni's Disarming Tool#9608 · Weapons | 31 | — | Off hand | Uncommon |
 Shinsollo#16171 · Consumables | 55 | 45 | No equipment slot | Common |
 Shindrell's Note#12060 · Quest items | 1 | — | No equipment slot | Common |
 Shiffar's Nexus-Horn#28418 · Armor | 115 | 70 | Trinket | Rare |
 Shekketh Talons#25187 · Weapons | 90 | 60 | Off hand | Uncommon |
 Shay's Bell#9189 · Quest items | 1 | — | No equipment slot | Common |
 Shaw's Report#1353 · Quest items | 1 | — | No equipment slot | Common |
 Shawn's Super Special Swami Hat#12904 · Armor | 61 | 61 | Head | Uncommon |
 Shani's Crysknife#31759 · Weapons | 94 | — | One-hand | Rare |
 Shango's Pelt#38523 · Quest items | 1 | — | No equipment slot | Common |
 Shaffar's Wondrous Amulet#33835 · Quest items | 1 | — | No equipment slot | Common |
 Shaffar's Stasis Chamber Key#32079 · Keys | 1 | — | No equipment slot | Uncommon |
 Shaffar's Wrappings#28490 · Quest items | 1 | — | No equipment slot | Common |
 Shaffar's Band of Brutality#31920 · Armor | 100 | 70 | Finger | Epic |
 Shadra's Venom#9324 · Quest items | 1 | — | No equipment slot | Common |
 Shadowmourne Monster Offhand#50815 · Weapons | 132 | 70 | One-hand | Epic |
 NPC Equip 50256#50256 · Weapons | 0 | — | One-hand | Poor |
| NPC Equip 50251#50251 · Weapons | 0 | — | Off hand | Poor |
| NPC Equip 50257#50257 · Weapons | 0 | — | One-hand | Poor |
 Glider's Boots#30681 · Armor | 115 | 70 | Feet | Epic |
 Glider's Greaves#30683 · Armor | 115 | 70 | Feet | Epic |
 Glider's Sabatons#30682 · Armor | 115 | 70 | Feet | Epic |
| Glider's Foot-Wraps#30680 · Armor | 115 | 70 | Feet | Epic |
 Shaarde the Greater#25944 · Weapons | 97 | 64 | Two-hand | Rare |
 Shaarde the Lesser#25964 · Weapons | 100 | 65 | One-hand | Rare |
 Sha'ni's Ring#11869 · Armor | 53 | — | Finger | Uncommon |
 Sha'ni's Nose-Ring#11058 · Quest items | 1 | — | No equipment slot | Common |