 Scalpel-Sharpening Shoulderguards#51014 · Armor | 251 | 80 | Shoulder | Epic |
 Scalpel-Sharpening Shoulderguards#51865 · Armor | 264 | 80 | Shoulder | Epic |
 Scalpel of the Royal Apothecary#45214 · Weapons | 200 | 80 | Main hand | Epic |
 Thunderlord Scalpel#31475 · Weapons | 105 | — | Main hand | Uncommon |
 Bloodscalp Scalp#6850 · Quest items | 1 | — | No equipment slot | Common |
 Skadi's Iron Belt#37379 · Armor | 200 | 80 | Waist | Rare |
 Sjonnir's Girdle#37670 · Armor | 200 | 80 | Waist | Epic |
 Sixen's Skullcap#43840 · Armor | 174 | — | Head | Uncommon |
 Whistling Sword#31541 · Weapons | 108 | — | One-hand | Uncommon |
 Siren's Tear#36784 · Gems | 75 | — | No equipment slot | Rare |
 Sintar's Vaccine#36807 · Quest items | 1 | — | No equipment slot | Common |
 Sinok's Key Fragment#36754 · Quest items | 1 | — | No equipment slot | Common |
 Sinister Revenge#40386 · Weapons | 226 | 80 | One-hand | Epic |
 Songbird Blouse#13378 · Armor | 58 | 53 | Chest | Rare |
 Singing Crystal Shard#3918 · Quest items | 1 | — | No equipment slot | Common |
 Singing Dagger#36679 · Weapons | 170 | 77 | Main hand | Uncommon |
 Singing Blue Crystal#3917 · Quest items | 1 | — | No equipment slot | Common |
 Singing Crystal Axe#31318 · Weapons | 100 | 70 | Two-hand | Epic |
| Chanting Blade#14151 · Weapons | 18 | 13 | One-hand | Rare |
 Sindragosa's Flawless Fang#50361 · Armor | 264 | 80 | Trinket | Epic |
| Sindragosa's Flawless Fang#50364 · Armor | 277 | 80 | Trinket | Epic |
 Sindragosa's Cruel Claw#50421 · Armor | 264 | 80 | Neck | Epic |
| Sindragosa's Cruel Claw#50633 · Armor | 277 | 80 | Neck | Epic |
 Simone's Head#18952 · Quest items | 1 | — | No equipment slot | Common |
 Simone's Cultivating Hammer#22380 · Weapons | 65 | — | Main hand | Rare |
 Silixiz's Tower Key#8072 · Keys | 1 | 1 | No equipment slot | Common |
 Silithid Husked Launcher#21800 · Weapons | 68 | 60 | Ranged | Rare |
 Silithid Ripper#8224 · Weapons | 36 | 31 | One-hand | Uncommon |
 Silithid Ichor#5269 · Miscellaneous | 1 | — | No equipment slot | Poor |
 Silithid Talon#5854 · Quest items | 1 | — | No equipment slot | Common |