 Solanian's Journal#20472 · Consumables | 1 | — | No equipment slot | Common |
 Solanian's Scrying Orb#20470 · Consumables | 1 | — | No equipment slot | Common |
 Sole-Less Boots#39205 · Armor | 5 | 4 | Feet | Poor |
 Surge Needle Ring#40474 · Armor | 213 | 80 | Finger | Epic |
 Instant Toxin#5654 · Miscellaneous | 24 | 24 | No equipment slot | Common |
 Instant Poison VIII#43230 · Consumables | 73 | 73 | No equipment slot | Common |
| Instant Poison VII#21927 · Consumables | 68 | 68 | No equipment slot | Common |
| Instant Poison VI#8928 · Consumables | 60 | 60 | No equipment slot | Common |
| Instant Poison V#8927 · Consumables | 52 | 52 | No equipment slot | Common |
| Instant Poison IX#43231 · Consumables | 79 | 79 | No equipment slot | Common |
| Instant Poison IV#8926 · Consumables | 44 | 44 | No equipment slot | Common |
| Instant Poison III#6950 · Consumables | 36 | 36 | No equipment slot | Common |
| Instant Poison II#6949 · Consumables | 28 | 28 | No equipment slot | Common |
| Instant Poison#6947 · Consumables | 20 | 20 | No equipment slot | Common |
 Sodalite Band#25054 · Armor | 111 | 67 | Finger | Uncommon |
 Socrethar's Teleportation Stone#29699 · Consumables | 0 | — | No equipment slot | Common |
| Socrethar's Teleportation Stone#29796 · Consumables | 0 | — | No equipment slot | Common |
 Socrethar's Head#29805 · Consumables | 0 | — | No equipment slot | Common |
 Socrethar's Girdle#30372 · Armor | 109 | — | Waist | Rare |
 NPC Equip 44730#44730 · Armor | 0 | — | Head | Poor |
 Snellig's Snuffbox#3619 · Quest items | 1 | — | No equipment slot | Common |
 Smotts' Chest#3932 · Quest items | 1 | — | No equipment slot | Common |
 Smotts' Compass#4130 · Armor | 50 | — | Trinket | Uncommon |
 Smotts' Cutlass#3935 · Weapons | 25 | 20 | One-hand | Common |
 Tuxedo Jacket#10036 · Armor | 1 | — | Chest | Common |
 Tuxedo Pants#10035 · Armor | 35 | 1 | Legs | Common |
 Tuxedo Shirt#10034 · Armor | 1 | — | Shirt | Common |
 Smokey's Drape#17523 · Armor | 58 | — | Back | Uncommon |
 Smokey's Explosive Launcher#16992 · Weapons | 60 | — | Ranged | Uncommon |
 Smokey's Special Compound#15736 · Quest items | 1 | — | No equipment slot | Common |