 Laughing Skull Tunic#24607 · Armor | 90 | 60 | Chest | Uncommon |
 Skull-Forged Blunderbuss#38246 · Weapons | 138 | — | Ranged | Rare |
 Skullspell Orb#10708 · Armor | 52 | — | Held in off-hand | Uncommon |
 Shepherd's Girdle#3753 · Armor | 34 | — | Waist | Uncommon |
 Shepherd's Gloves#3754 · Armor | 33 | — | Hands | Uncommon |
 Sheepshear Mantle#13115 · Armor | 45 | 40 | Shoulder | Rare |
 Shaft of Glacial Ice#50998 · Weapons | 251 | 80 | Two-hand | Epic |
| Shaft of Glacial Ice#51881 · Weapons | 264 | 80 | Two-hand | Epic |
 Walnut Stock#40533 · Trade goods | 80 | — | No equipment slot | Common |
 Shawl of the Old Maid#40253 · Armor | 213 | 80 | Back | Epic |
 Shawl of the Refreshing Winds#46976 · Armor | 245 | 80 | Back | Epic |
| Shawl of the Refreshing Winds#46977 · Armor | 258 | 80 | Back | Epic |
| Shawl of Haunted Memories#45529 · Armor | 226 | 80 | Back | Epic |
| Shawl of Shifting Probabilities#29369 · Armor | 110 | 70 | Back | Epic |
 Shawl of Wonderment#34202 · Armor | 159 | 70 | Shoulder | Epic |
| Shawl of Fervent Crusader#48672 · Armor | 258 | 80 | Back | Epic |
 Shawl of the Devout Crusader#48667 · Armor | 258 | 80 | Back | Epic |
 Inquisitor's Shawl#19507 · Armor | 41 | 36 | Shoulder | Rare |
 Shadow Vault Shawl#43925 · Armor | 174 | — | Back | Uncommon |
 Shawl of the Caretaker#45317 · Armor | 219 | 80 | Back | Epic |
| Shawl of the Shattered Giant#45704 · Armor | 219 | 80 | Back | Epic |
 Shellfish#13545 · Quest items | 1 | — | No equipment slot | Common |
 Shucking Gloves#15405 · Armor | 17 | — | Hands | Uncommon |
 Sonic Spear#27903 · Weapons | 115 | 70 | Two-hand | Rare |
 NPC Equip 33542#33542 · Weapons | 0 | — | One-hand | Poor |
 NPC Equip 33543#33543 · Weapons | 0 | — | One-hand | Poor |
 Shamanistic Helmet of Second Sight#31107 · Armor | 109 | — | Head | Rare |
 Nefarious Buckler#4477 · Armor | 34 | 29 | Shield | Uncommon |
 Vilerend Slicer#11603 · Weapons | 51 | 46 | Main hand | Rare |
 Geistlord's Punishment Sack#50073 · Armor | 264 | 80 | Head | Epic |